De wetenschap achter de cursus
Rebuilding The Gut is geen verzameling meningen. De inhoud rust op peer-reviewed onderzoek. Hieronder vind je de dragende werken die door de hele cursus heen liggen, plus de belangrijkste bronnen per module en protocol. Elke referentie is gecontroleerd op auteur, jaar en tijdschrift — geen verzonnen verwijzingen.
Fundamentele werken (door de hele cursus heen)
- Sonnenburg, E.D. & Sonnenburg, J.L. (2014). Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates. Cell Metabolism, 20(5), 779–786.
- David, L.A., Maurice, C.F., Carmody, R.N., et al. (2014). Diet rapidly and reproducibly alters the human gut microbiome. Nature, 505, 559–563.
- Cryan, J.F. & Dinan, T.G. (2012). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 13(10), 701–712.
- Cryan, J.F., O'Riordan, K.J., Cowan, C.S.M., et al. (2019). The Microbiota-Gut-Brain Axis. Physiological Reviews, 99(4), 1877–2013.
- Mayer, E.A. (2011). Gut feelings: the emerging biology of gut-brain communication. Nature Reviews Neuroscience, 12(8), 453–466.
- Fasano, A. (2011). Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiological Reviews, 91(1), 151–175.
Module 1 — Welkom in jouw darm
- Sonnenburg & Sonnenburg (2014) — vezels & microbioom-diversiteit
- David et al. (2014) — voeding verandert het microbioom binnen dagen
- Fasano (2011) — darmbarrière, tight junctions, zonuline (lekkende darm)
- Cryan & Dinan (2012); Cryan et al. (2019); Mayer (2011) — darm-hersen-as
- Sender, R., Fuchs, S. & Milo, R. (2016). Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biology, 14(8), e1002533. — verhouding microben:eigen cellen ≈ 1:1
- Claesson, M.J., Jeffery, I.B., et al. (2012). Gut microbiota composition correlates with diet and health in the elderly. Nature, 488(7410), 178–184. — ELDERMET; microbioom, voeding & veroudering
- Rook, G.A.W., Lowry, C.A. & Raison, C.L. (2013). Microbial 'Old Friends', immunoregulation and stress resilience. Evolution, Medicine, and Public Health, 2013(1), 46–64. — "old friends"-/hygiënehypothese
Module 3 — Wat vertelt jouw darm je?
- Chedid et al. (2014) — overgroei/behandeling (zie protocol 10.2)
- Parodi, A., Paolino, S., Greco, A., Drago, F., Mansi, C., Rebora, A., Parodi, A. & Savarino, V. (2008). Small Intestinal Bacterial Overgrowth in Rosacea: Clinical Effectiveness of Its Eradication. Clinical Gastroenterology and Hepatology, 6(7), 759–764. — darm-huid-as: rosacea & SIBO, verbetering na eradicatie
- Stokes, J.H. & Pillsbury, D.M. (1930). The effect on the skin of emotional and nervous states: theoretical and practical consideration of a gastrointestinal mechanism. Archives of Dermatology and Syphilology, 22(6), 962–993. — klassieke darm-brein-huid-hypothese
- Bowe, W.P. & Logan, A.C. (2011). Acne vulgaris, probiotics and the gut-brain-skin axis – back to the future? Gut Pathogens, 3(1), 1. — moderne darm-brein-huid-review (acne)
- Plottel, C.S. & Blaser, M.J. (2011). Microbiome and malignancy. Cell Host & Microbe, 10(4), 324–335. — introduceert het 'estrobolome' (darm & oestrogeen via bèta-glucuronidase)
Module 4 — Wat heeft jouw microbioom beschadigd?
- David et al. (2014) — dieet-effect
Module 5 — Hoe herstel werkt
- Sonnenburg & Sonnenburg (2014) — vezels (MACs) & SCFA-productie
- Tomás-Barberán, F.A., González-Sarrías, A., García-Villalba, R., Núñez-Sánchez, M.A., Selma, M.V., García-Conesa, M.T. & Espín, J.C. (2017). Urolithins, the rescue of "old" metabolites to understand a "new" concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. Molecular Nutrition & Food Research, 61(1), 1500901. — polyfenolen → urolithinen door darmbacteriën; individuele metabotypes
Module 6 — Jouw fundament leggen
- Cryan et al. (2019) — stress & darm-hersen-as
10.1 — PDS (prikkelbare darm)
- Halmos, E.P., Power, V.A., Shepherd, S.J., Gibson, P.R. & Muir, J.G. (2014). A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology, 146(1), 67–75.
- Böhn, L., Störsrud, S., Liljebo, T., et al. (2015). Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial. Gastroenterology, 149(6), 1399–1407.
10.2 — SIBO / IMO / Schimmelovergroei
- Chedid, V., Dhalla, S., Clarke, J.O., et al. (2014). Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Global Advances in Health and Medicine, 3(3), 16–24.
10.8 — Obesitas / overgewicht
- Depommier, C., Everard, A., Druart, C., et al. (2019). Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine, 25(7), 1096–1103.
- Kadooka, Y., Sato, M., Imaizumi, K., et al. (2010). Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. European Journal of Clinical Nutrition, 64(6), 636–643.
- Kadooka, Y., Sato, M., Ogawa, A., et al. (2013). Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. British Journal of Nutrition, 110(9), 1696–1703.
10.9 — Auto-immuunziekten
- Fasano, A. (2011). Zonulin and its regulation of intestinal barrier function. Physiological Reviews, 91(1), 151–175.
- Fasano, A. (2012). Leaky Gut and Autoimmune Diseases. Clinical Reviews in Allergy & Immunology, 42(1), 71–78.
10.10 — Neurodegeneratieve ziekten
- Svensson, E., Horváth-Puhó, E., Thomsen, R.W., et al. (2015). Vagotomy and subsequent risk of Parkinson's disease. Annals of Neurology, 78(4), 522–529.
- Liu, B., Fang, F., Pedersen, N.L., et al. (2017). Vagotomy and Parkinson disease: A Swedish register-based matched-cohort study. Neurology, 88(21), 1996–2002.
10.11 — Hart- en vaatziekten
- Tang, W.H.W., Wang, Z., Levison, B.S., et al. (2013). Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. New England Journal of Medicine, 368(17), 1575–1584.
- Koeth, R.A., Wang, Z., Levison, B.S., et al. (2013). Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine, 19(5), 576–585.
- Estruch, R., Ros, E., Salas-Salvadó, J., et al. (2013). Primary prevention of cardiovascular disease with a Mediterranean diet (PREDIMED). New England Journal of Medicine, 368(14), 1279–1290.
Deze lijst groeit mee met de cursus en wordt per hoofdstuk verder aangevuld. De medische eindverantwoordelijkheid ligt bij Joeri; de cursus is educatief en een aanvulling op, geen vervanging van, medische zorg.